Monocyte Activation Test (MAT) Market – Global Outlook & Forecast 2021-2031

Monocyte Activation Test (MAT) Market by Product Type [Kits & Reagents and Services], Source [Whole Blood, Peripheral Blood Mononuclear Cell (PBMC) and Cell Line], End User [Pharmaceutical Industry and Biotechnology Industry] – Global Analysis & Forecast 2021-2031

Clairvoyance Research conducted an in-depth market analysis study of the global monocyte activation tests (MAT) market. According to the study, the market was valued at ~US$ 7.5 million in 2020. The market is expected to witness a CAGR of ~13.0% from 2021 to 2031. 

Rising incidences of chronic diseases & pandemic, increasing investment for the development & launch of innovative drugs to meet the needs of healthcare sector, and favorable regulatory policies are some of the pivotal factors propelling the growth of the monocyte activation tests (MAT) market. However, inadequate supply of the human blood with viable monocytes and complex production process of peripheral blood mononuclear cell (PBMC) are likely to restrain the market growth to a certain extent.

Government bodies and numerous organizations across the globe are implementing several initiatives, regulations & protocols for pyrogen testing, owing to the increasing public & regulatory concerns over product safety. According to article number 21 CFR 610 of USFDA, respective industries should ensure that the pyrogen concentrations do not exceed the contaminant limits specific to each product. Companies cannot release their products into the market unless they standardize them as per the rules and upon violation of the law by companies, FDA is liable to take legal action against them. This factor is expected to boost the market of the pyrogen tests such as MAT in the forecast period.

There have been continual efforts to ban the use of animals for testing all over the world. In rabbit pyrogen test (RPT), rabbits suffer from painful reactions including fever, breathing problems, circulatory & organ failure, and even fatal shocks. Similarly, a large number of horseshoe crabs are harvested for limulus amoebocyte lysate (LAL) Tests, which has led to a decline in three Asian horseshoe crab species. Therefore, to save horseshoe crab species from extinction and to end cruelty to rabbits, several organizations, such as PETA and various Pharmacopeias, recommended the use of non-animal test methods such as MAT. This factor is also expected to propel the growth of the market.

In order to be competitive in the market several prominent players are progressively implementing several strategies such as technological advancements, acquisitions and/or collaborative initiatives with several organizations, research centers & companies for R&D activities. For instance, in Oct 2020, Lonza launched its PyroCell™ MAT System, a highly sensitive and sustainable Monocyte Activation Test (MAT) suitable for detecting a broad range of pyrogens without the need for experimental animals.

However, inadequate supply of the human blood with viable monocytes and complex production process of peripheral blood mononuclear cell (PBMC) for the test may hamper the growth of market to a certain extent. Lower sensitivity & longer time of result of MAT test as compared to LAL tests is also expected to hinder the growth of the market.

The Asia Pacific region is expected to witness the highest CAGR in the forecast period. Factors such as developing healthcare infrastructure, rising R&D investments by prominent players to develop & launch parenteral formulation for various diseases and increasing approval of various biologics & vaccines can be attributed to the growth of the market. Countries such as India, China and Japan in the APAC region, are projected to offer significant growth opportunities owing to presence of large patient pool and booming pharmaceutical & biotechnology industry in the region.

The monocyte activation tests (MAT) market is marked by presence of prominent players such as Merck KGaA, BD, Charles River Laboratories, Thermo Fisher Scientific, Sanquin, Lonza, Microcoat Biotechnologie GmbH, SOLVIAS AG.

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